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Microscopy and stains in histology
Immune sera, Antibodies
Markers and conjugates
Tissue preparation
Immuno-staining, other ligand detection
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Applied cell labeling  

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HomeCell-MarkerSelection of staining protocols → Immunofluorescence assay for autoantibodies to nuclear antigens (ANA) on HEp-2 cells




Wolf D. Kuhlmann

Labor - Diagnostik - Beratung, D-56112 Lahnstein, Germany
MVZ für Laboratoriumsmedizin Koblenz-Mittelrhein, D-56068 Koblenz, Germany



Anti-nuclear antibody (ANA) testing by indirect immunofluorescence (IFT) is a fundamental laboratory method for the detection of antibodies in autoimmune diseases such as systemic autoimmune rheumatic diseases (SARD) from which clinical entities such as lupus erythematosus, mixed connective tissue disease, Sjögren’s syndrome, systemic sclerosis, polymyositis, dermatomyositis and overlap syndromes are typical examples. ANA is a hallmark for diagnosing and differentiating such diseases.

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